FIND ARTICLE

THE ROLE OF CALCIUM IONS IN ACTIVATION OF THE MAMMALIAN EMBRYO DEVELOPMENT

Fertilization of a mouse oocyte triggers oscillations of the concentration of free calcium ions in ooplasm ([Ca2+] i ). Calcium oscillations are generated in a process involving inositol 1,4,5-triphosphate (IP 3 ) produced by phospholipase C zeta (PLC zeta), a sperm specific isoform of phospholipase C. Calcium transients last for several hours until the time of pronuclei formation. The ability to generate and sustain long-lasting oscillations of [Ca2+] i is developed in oocytes during meiotic maturation, i.e.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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