Endothelial Progenitor Cells: origin, characteristics and prospects of use in therapy

Vascular endothelium and the blood cells are derived from mesodermal cells of the common hemangioblastu. The confirmation of the close relationship of both cell lines are common antigens, occurring in the early stages of differentiation. Endothelial precursor cells, defined as CD34 + CD133 + Flk-1 +, can be differentiated in vitro cultured endothelial cells. Progenitors of endothelial cells, isolated from bone marrow, cord blood and peripheral blood in vivo may incorporate into the vessel wall and damaged endothelial function to take.

Genetic instability in nowotworach.II. Microsatellite instability and loss of heterozygosity

Genetic instability is one of the most characteristic features of cancer cells. It is expressed in the cell accumulation of chromosomal aberrations and mutation, as well as microsatellite instability and loss of heterozygosity. Microsatellite instability (MSI) is a mutator phenotype characteristic. It occurs in hereditary and sporadic cancers, although with different frequencies. MSI is to change the length (size) alleles by increasing or reducing the number of nucleotide repeats.

Genetic instability in cancer. I. Chromosomal Instability in Cancer

Genetic instability, chromosomal or / and microsatellite is one of the characteristics of tumor cells. In tumor cells, both solid tumors and hematologic malignancies chromosomal instability expressed by the accumulation of structural and numerical aberrations of chromosomes. Chromosomal aberrations in tumors may be changes in specific, critical for the transition process, or secondary, which are the expression and at the same time cause genetic instability of cancer cells.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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