FIND ARTICLE

STRUCTURE AND FUNCTION OVIDUCT-SPECIFIC GLYCOPROTEIN 1

Oviduct specific glycoprotein 1 (OVGP1) also known as pOSP, MUC-9, sOP92, EAP, EGP and OGP, is produced by non-ciliated oviductal epithelium in many mammalian species. After its secretion to the oviductal fluid OVGP1 participates in the final gamete maturation, sperm capacitation, fertilization and supports early embryonic development. Secretion and expression of OVGP1 is regulated by steroid hormones and depends on the oestrus cycle. Molecular analysis of OVGP1 indicated that it is highly conserved at both amino acid and nucleotide levels.

MECHANISMS OF RNA DEGRADATION IN YEAST AND MAMMALIAN CELLS

RNA degradation in yeast and mammalian cells take place in cytoplasm, nucleus and mitochondria. Degradation of transcripts with a premature termination codon or without stop codon results in repression of aberrant protein synthesis. The mRNA decay pathway, which degrades mRNAs containing a stem-loop structure has been discovered and characterized in the yeast Saccharomyces cerevisiae. Eukaryotic transcripts with AU-rich elements in their 3'-untranslated region have a very short half-life. These elements regulate mRNA level in cells.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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