FIND ARTICLE

SIGNIFICANCE OF REGULATORY T CELLS IN THE DEVELOPMENT OF TOLERANCE TO TUMOR

Immune cells infiltrate tumors and make up a significant component of the multicellular cancer microenvironment, yet the immune system often fails to prevent tumor formation and progression. One explanation for this paradox is the presence of tolerance-promoting regulatory T cells (Tregs). Tregs were known to be essential for maintaining self-tolerance. Tregs have been found to promote tolerance to tumors in mouse models. Treg infiltration in human tumors and malignant ascites is associated with worse clinical outcomes for various types of cancers.

APPLICATION OF BIOINFORMATIC TOOLS FOR THE ASSESSMENT OF GENE AND PROTEIN STRUCTURE AND FUNCTION: NCAM MOLECULE AS AN EXAMPLE

Rapid progress of biological and medical research depends largely on steadily growing informa- tion in online databases and its accessibility for researchers. All centers involved in the collection of nucleotide and aminoacid sequences exchange and update available data. Full benefit from this information may be obtained only by proper analysis provided by several bioinformatic services. In their formation people from broad scientific community are engaged and their effects of work are accessible free of charge in internet.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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