FIND ARTICLE

STRUCTURE, FUNCTION AND ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA PPARg

Peroxisome proliferator-activated receptor-gamma (PPARg) is one of the most intensively studied nuclear receptors of the last two decades. The receptor owe its popularity to pleiotropic actions on many important physiologic processes of single cells and whole organisms such as energy homeodynamic regulation, control of glucose and lipid metabolism, proliferation, differentiation, apoptosis, inflammation or angiogenesis. Beside natural ligands some synthetic agonists, antagonists and modulators of PPARg are already known.

Focal Adhesion Kinase osteoblast biology

Focal Adhesion Kinase - FAK ( focal adhesion kinase) belongs to the group of non-receptor protein tyrosine kinases . It occurs in the cytoplasm of most cells , including osteoblasts. At the time of its activation , the interaction of integrin associated protein extracellular matrix call is incorporated into platelet adhesion . FAK kinase in the presence of these structures is closely related to a function that plays in cellular processes such as adhesion, migration, proliferation . FAK -deficient cells show a much slower growth and reduced mobility.

NKG2D receptor and its ligands

The effector cells of the immune system are able to recognize the infected cells , transformed , and how recently found , cells of various types of stressors . One way is to recognize the identification of the latter, stress-induced cell surface molecules . The best known receptor involved in this type of reaction is the C -type lectin receptor called NKG2D on NK cells present , TGD lymphocytes , CD8 + lymphocytes and macrophages Tab . Described 4 NKG2D ligand family .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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