FIND ARTICLE

Volume: 
Issue: 
1
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Hepcidin is an antimicrobial peptide mainly sythesized in hepatocytes and released into circulation as a prohormone. Recent evidence shows that hepcidin is the hormone regulating of iron homeostasis in the body. The lack of the hepcidin expression results in iron overload and overexpression of the hepcidin has been associated with iron deficiency anemia. The synthesis of the hepcidin is stimu- lated by high iron diet or inflammation and it is decreased by low iron diet, anemia or hypoxia. Evidence indicates that hepcidin is the negative regulator of iron absorption and iron release from macrophages of the reticuloendothelial system. The relationship between iron and hepcidin is disrupted in patients with hemochromatosis and anemia of chronic disease. The exact understanding the role of the hepcidin could lead to new therapies for disorders of the iron metabolism.

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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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