Nucleotides are among the most important compounds in all living organisms. They partici- pate in many biochemical processes in cells. They are precursors for nucleic acid synthesis, an energy source and precursors for components of primary and secondary metabolic products. Therefore, the metabolism of nucleotides are crucial for the growth and development of all organisms. In the present review we have concentrated on nucleotides’ metabolism and physiological aspects of these processes during different morphogenetic processes, including embryo maturation and seed germination, storage organ development, sprouting and growth of cultured plant cells. The effects of environmental factors on nucleotide metabolism are also described.