Endothelial cells play a critical role in blood circulation and hemostasis, in arteriosclerosis, inflamation and cancer progression. Low cellular turnover, and migration and proliferation capacity in response to specific stimuli are characteristic features of endothelial cells. High endothelial venules in lymph nodes are the type of endothelium specialised in lymphocyte circulation. E selectin and other endothelium specific adhesive molecules called addressins, initiate process of leukocytes' adhesion to the vascular wall. Under influence of chemokines activated leukocytes adhere firmly and finaly transmigrate through the vascular wall to the surronding tissues. The knowlege of adhesive molecules and their activators/inhibitors, participating in the process, would possibly allow a specific antiadhesive therapy of inflamatory and neoplastic diseases.