Synucleins are a family of small (15–20 kDa), soluble, conserved proteins that are predominan- tly expressed in neurons and include α-, β-, γ-Synuclein and Synoretine. Among the synuclein family exclusively α-Synuclein is the precursor protein for highly hydrophobic 35-amino acid peptide NAC (non-amyloid β component of Alzheimer’s disease plaques). This presynaptic protein associated with synaptic vesicles is also present in cytosol. Under physiological conditions α-Synuclein is natively unfolded.