FIND ARTICLE

BREFELDIN A – AN INSIGHT INTO THE FUNCTIONING OF THE MEMBRANE SYSTEM OF PLANT CELLS

The functioning of eukaryotic cells is strictly dependent on the proper vesicular traffic within the cell’s membrane system. Brefeldin A – a fungal toxin, disturbs this traffic, enabling an experimen- tal insight into the organisation and co-operation of various elements of the system. Recently, BFA target proteins and sites of action have been identified. In this paper, we analyse the mechanism of BFA functioning and indicate those particular properties of the membrane system of plant cells that determine some of the reactions to BFA that are specific to plants.

Diverse forms of clathrin coated vesicles in receptor mediated transport and segregation of macromolecules

In mammalian cells the clathrin coated vesicles participate in receptor mediated internalization, transport and sorting of macromolecules from the trans Golgi network to the endocytic pathway as well as from the plasma membrane to endosomes and lysosomes. The complex protein machinery controlling vesicle budding, transport and fusion are significantly conserved between the endocytic and sorting pathways. The internalization and intracellular transport are based respectively on tyrosine (YXXĆ) and dileucine (LL) signals.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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