FIND ARTICLE

GENE'S POLYMORPHISM OF DNA DOUBLE-STRAND BREAKS REPAIR IN BREAST CANCER

Breast cancer is one of the most often female cancers. From the last few years in Poland morbidity increased about 4 5%. This cancer is also cause of the major part of deaths caused by malignant tumors. Etiology of most cases of breast cancer is not possible to determine. The most important risk factors are age and breast cancer occurrence in first and/or second step relatives. Germinal mutations in two major high penetrance genes, BRCA1 and BRCA2 are responsible for high risk of cancer development but they constitute less than 5% of all cases of this cancer.

GENETIC POLYMORPHISM OF THE ESTROGEN BIOSYNTHESIS PATHWAY KEY ENZYMES IN WOMEN

Endogenous estrogens play an important role in women's organism: they control menstrual cycle through the influence on foliculogenesis, ovary's steroidogenesis and growth, and endometrium transformations. But their role is not only confined to ovaries and testis action. Number of researches report about systemic role of these hormones in women. They are involved in lipids and carbohydrates metabolism, bone mineralization, vascular functions. Estrogens are synthesized not only in gonads, but also in adipose cells, bones, brain, vasculature and adrenal cortex.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

PBK Postępby biologi komórki