FIND ARTICLE

INTERLEUKIN 15 - WHAT DO WE KNOW? THE STRUCTURE, RECEPTORS AND INHIBITORS

Interleukin 15 (IL-15) is a pleiotropic cytokine with a wide spectrum of activity. The significant role of IL-15 in the pathogenesis of inflammatory and autoimmune processes, infectious diseases and cancer suggests a possibility of a therapeutic intervention by blocking the biological activity of this cytokine.

ROLE OF INTERLEUKIN 15 IN PATHOGENESIS AND THERAPY OF HUMAN DISEASES

Interleukin 15 (IL-15) is a cytokine with strong impact on immunological system, that affects pathogenesis of multiple human disorders. Naturally, it participates in antiviral defence. Infected peripheral blood mononuclear cells secrete IL-15 which, via its impact on NK cells and T lymphocytes, exerts antiviral properties. IL-15 may find its application in HIV infection treatment. Stimulating proliferation of antigen- activated T cells and inhibiting their apoptosis, IL-15 may counteract AIDS-associated lymphocytopaenia.

INTERLEUKIN 15: GENERAL CHARACTERISTICS AND ACTIVITY IN PHYSIOLOGICAL CONDITIONS

Interleukin 15 (IL-15) is a cytokine that reveals multiple actions on immune system. Initially it was thought to resemble IL-2, but there is still growing evidence that IL-15 has multiple, unique properties, in some cases acting opposingly to IL-2. IL-15 influences mechanisms of both innate and acquired immunity. It induces differentiation and proliferation of NK cells, increases their cytotoxic properties and ability of IFN-γ secretion and also serves as chemoattractant for them. IL-15 acts also on macrophages/monocytes as well as on neutrophils.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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