FIND ARTICLE

REGENERATIVE AND IMMUNOMODULATORY PROPERTIES OF ADIPOSE-DERIVED MESENCHYMAL STEM CELLS

Many studies on medical application of adipose-derived mesenchymal stem cells are currently performed. Regenerative and immunomodulatory properties of these cells are very promising. In this paper we review the literature concerning differentiation potential of adipose-derived stem cells and their effects on immune response. We demonstrate the clinical application of these cells and, shortly, their phenotype and isolation methods.

THE ROLE OF STEM CELLS IN THE PROCESS OF ENDOGENIC REGERATION OF CENTRAL NERVOUS SYSTEM BASED ON SELECTED VASCULAR DISEASES

Central nervous system (CNS) is seen as crucial in the organism and plays critical role in regulation and decision making processes on multisystem and behavioral level. The variety of diseases affecting CNS, and lack of effective therapy raises a question of chance of maintenance or recovery of the nervous function within the organism own forces. The presence of heterogenic population of stem (SCs) and progenitor cells in various regions of the retina and brain is well documented.

PARTICIPATION OF 'NON-MUSCLE' STEM CELLS IN REGENERATION OF SKELETAL MUSCLE

Skeletal muscle tissue is characterized by ability to regenerate in response to injury resulting for example from mechanical trauma, toxin or disease. The key role in this process is played by satellite cells localized in skeletal muscle. However, both under physiological and experimental conditions different types of stem cells originating either from skeletal muscle or other tissues can be also involved in regeneration. This raises the hope for potential use of stem cells in the therapy for skeletal muscles diseases, such as muscular dystrophies or spinal muscle atrophy.

VERY SMALL EMBRYONIC LIKE STEM CELLS (VSELS) ISOLATED FROM ADULT TISSUES - AN UPDATE

Accumulating evidence demonstrates that adult tissues contain a population of very pluripotent stem cells and recently our group identified a population of very small stem cells in murine bone marrow and other adult organs that express several markers characteristic for

Family of trefoil peptides

The trefoil family of peptides is mainly associated with gastrointestinal tract. These peptides protect the mucous layer. The protective role of trefoil peptides is explained by their interaction with carbohydrates attached to mucin glycoproteins and by maintenance of the mucus structure. Trefoil peptides influence migration of epithelial cells and thus contribute to regeneration of the mucous layer. A correlation between trefoil peptides and oncogenesis remains unclear.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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