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DEGRADATION OF TRUNCATED mRNA IN EUKARYOTIC AND PROKARYOTIC CELLS

Cells have evolved mechanism to get rid of nonfunctional or potentially deleterious proteins that are coded by mRNA with premature translation termination or mRNA without stop codon. The pathway of degradation of such mRNA have been described in mammals, flies, nematodes, yeast and plants. The degradation steps as well as factors involved in are not identical in different species. The general way of recognition of aberrant transcripts depends on spatial relationship between ribosome components and ribonucleoproteins bound to the 3’UTR sequence.

Effect of maturation of the plant mitochondrial transcripts on their stability

Transcripts of mitochondrial genes before they fully transform into mature mRNA , subject to few modifications posttranscriptional , which include splicing , editing and processing of three and 5 the end of the transcripts . Post-transcriptional processes leading to the formation of mature , functional mRNA is regulated by factors that stabilize or degrade these particles . The level of stable mitochondrial RNA is associated primarily with the transcriptional activity of the gene which is affected , inter alia, the construction of the promoter and the gene copy number .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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