The role of Rel proteins / NFkB / IkB in the pathogenesis of cancer

Rel family of transcription / NFkB / IkB plays an important role in the regulation of a number of processes related to immune and inflammatory responses and control the growth of normal and neoplastic cells. In the present knowledge of the structure of proteins Rel / NF-kB / IkB, mechanisms of action, physiological significance, and discusses their role in the pathogenesis of retroviral-induced cancers and other human cancers, especially leukemias and lymphomas. The paper presents a method of counteracting the disturbances in this family of proteins leading to tumorigenesis.

Inhibition of post-translational modification of RAS proteins as a new method of cancer therapy

RAS proteins play a key role in regulating growth and differentiation of cells taking part in the activation of intracellular relay chain. Ras gene mutations, observed in approximately 30% of cancers in humans leads to the production of RAS proteins transmit signals to the cells not subject to regulation by extracellular cytokines. That for the operation of the RAS proteins, it is necessary their combination with the cell membrane, which depends on the reaction involving the farnesylation of farnesyl transferase, leading to synthesize compounds which inhibit the enzyme.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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