Peroxisome proliferator-activated receptor-gamma (PPARg) is one of the most intensively studied nuclear receptors of the last two decades. The receptor owe its popularity to pleiotropic actions on many important physiologic processes of single cells and whole organisms such as energy homeodynamic regulation, control of glucose and lipid metabolism, proliferation, differentiation, apoptosis, inflammation or angiogenesis. Beside natural ligands some synthetic agonists, antagonists and modulators of PPARg are already known.