Transport synthesized in the endoplasmic reticulum (ER) of macromolecules occurs by an protein complex coated vesicles COP COP I and II. Polymorphic tubularno-vesicular intermediate compartment (IC VTCs or ERGIC) located between the endoplasmic reticulum and cis-Golgi cisterns, participates in the regulation of the transport and sorting of macromolecules through the processes of recognition of a signal sequence. For example, the sequence difenyloalaninowa (FF) of ER export signal sequence dilizynowa (KKXX) is, however, essential for the desired protein to the endoplasmic reticulum.