FIND ARTICLE

FIBROBLAST ACTIVATION PROTEIN a - CONTRIBUTION IN TISSUES WOUND HEALING AND CANCEROGENESIS

Fibroblast activation protein a (FAPa) also known as seprase belongs to type II integral membrane proteins. FAPa/seprase bounded to cell membrane is serine proteinase with gelatinase activity. Serine proteases family included among others S9B post-prolyl dipeptidyl aminopeptidase subfamily. Besides FAPa/seprase, to S9B subfamily belongs dipeptidyl peptidase IV (DPPIV). Catalytically active FAPa is a 170 kDa homodimer, consisting of two 97 kDa subunits. FAPa besides homodimers also forms heteromeric, catalytically active complexes with DPPIV.

The role of connective tissue growth factor in the development of processes and fibroproliferative diseases leading to tissue fibrosis

Connective tissue growth factor - CTGF ( connective tissue growth factor ) was discovered in 1991 by Bradhama in cultured human endothelial cells derived from umbilical vein . This protein has been isolated and identified as a potent mitogen , but the results of scientific studies in recent years indicate that CTGF is not only stimulates cell proliferation , but also possesses outstanding profibrotic properties . CTGF is a downstream mediator of TGF - ß in both normal and pathological processes of change in the connective tissue .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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