FIND ARTICLE

GHRELIN – REGULATION OF FEEDING, GROWTH HORMONE RELEASE AND OTHER ACTIONS OF A NEW HORMONE

Ghrelin, an acetylated peptide composed of 28 amino-acids, is an endogenous ligand for the growth hormone secretagogues receptor, GHS-R. Ghrelin is mainly produced by the X/A cells of the oxyntic glands in the stomach and, to a much lesser extent, in hypothalamus, pituitary, adrenal gland, intestine, gonads, heart, T lymphocytes, and monocytes. Ghrelin increases growth hormone secretion independently on and synergistically with somatoliberin.

The role of stellate cells (perisinusoidalnych) in the regulation of liver function. II. Interaction with other cells in the development of liver fibrosis.

Hepatic stellate cells play a key role in the development of liver fibrosis that is characterized by a quantitative and qualitative changes in the composition and distribution of the extracellular matrix . Under the influence of the compounds released from damaged hepatocytes and Kupffer cells Browicz - , platelets , white blood cells and endothelial cells , there is a transition ( activation ) stellate cells quiescent cells myofibroblast phenotype .

The role of stellate cells (perisinusoidalnych) in the regulation of liver function. I. Morphology and properties of stellate cells in situ and in cell culture.

Hepatic stellate cells (synonyms : lipocytes , perisinusoidalne liver cells , the cells accumulate lipids, Ito cells ) are located in the perisinusoidal space ( of Disse ) , and their basic morphological feature is the presence of numerous lipid vacuoles ( covering approximately 20% of the cell volume ) and long spike entangling often hepatic sinus wall . Under normal conditions , stellate cells comprise 70-80 % of the vitamin A in the body plays a key role in the metabolism of the compound.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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