Tri- II is a great peptydylpeptydaza cytoplasmic protease complex structure that cuts off the free end of the tripeptides of amino oligopeptides also has some activity endoproteolytic . TPPII cells present in all eukaryotes examined . Its structure is faithfully preserved by evolution . Proteasome participates with other peptidases and cytoplasmic protein degradation processes , but the specific substrates and the method of controlling TPPII activity have not yet fully understood . Both overexpression TPPII is detrimental to cells and the inhibition of gene transcription TPPII .