Apoptosis is the major form of cell suicide. Most conventional anticancer agents induce apoptosis indirectly. Although chemiotherapeutic drugs should selectively kill only tumor cells, normal cells are often susceptible to cytotoxic or cytostatic effects of these agents. This is a reason of potentially harmful side effects including inflammation and damage to the surrounding normal tissue. A new therapeu- tic approach in cancer treatment is the use of substances that stimulate cytokine production, angiogenesis inhibitors, gene therapies, antisense oligonucleotides and monoclonal antibodies.

Philadelphia chromosome (Ph) is the result of a chromosomal translocation leads to malignant transformation of hematopoietic cells . The reason is oncogenic tyrosine kinase activity of the BCR / ABL fusion gene resulting from following the transfer of a fragment of chromosome 9 to chromosome 22 [ t ( 9 , 22 )] . There is a whole family of tyrosine kinases fusion ( FTKs ) related to BCR / ABL , such as the TEL / ABL , TEL/JAK2 , TEL / TRKC (L) , TEL / PDGFâR and NPM / ALK , which induce both acute and chronic myelogenous leukemias and lymphomas.