Was studied by fluorescence spectroscopy methods of anticancer drugs doxorubicin interaction (DOX ) and paclitaxel ( PTX ) on the properties of the plasma membrane of cells of MCF- 7 breast adenocarcinoma . Used fluorescent probes TMA- DPH and Daud , allow the determination of external liquidity , the polar regions and the hydrophobic core of the lipid bilayer . It was found varying effects of both drugs . DOX and PTX influenced differently at the surface and the hydrophobic region of the membrane. Similar and DOX induced concentration-dependent changes in both areas of the lipid bilayer .