The role of thiols in platelet activation

Thiol compounds present in the cells can be divided into low molecular weight and protein . Protein thiol groups , derived from cysteine ​​, may be present as free thiols, disulfides and mixed disulfides in combination with a low molecular weight thiols : glutathione , cysteine ​​, homocysteine ​​, and ? - Glutamylocysteiną . Metabolic related reactions of thiols have an important role in platelet function , anucleate cells derived from megakaryocytes , and performing an important role in hemostasis .


Blood platelets, enucleate cells derived from megakaryocytes, play an essential role in haemo- stasis and thrombosis. They may be involved probably in platelet activation and programmed death. The experimental evidences discussed in this review indicate that during aging and activation platelets express apoptotic markers similar to those found in nucleated cells.

The role of reactive oxygen species in platelets

Reactive oxygen species ( ROS) , which include superoxide anion ( O2. ) , hydroxyl radical (OH) , hydrogen peroxide (H2O2) , singlet oxygen ( 1O2 ) and nitric oxide (NO) are highly reactive particles. Can react with lipids, proteins or DNA , causing irreversible changes in the structure of these compounds. Platelets , like other cells , can generate ROS , which are drawn into the mechanisms of activation of these cells . There are several ways to manufacture platelet RFT .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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