Since kisspeptin appeared on the stage of endocrinology of reproduction in 2003, its role as a key trigger of the complex aspects of reproduction and especially of the stimulation of gonadotrophin releasing hormone/luteinising hormone in females, was progressively explored and documented. The family of peptides called kisspeptins are products of KiSS-1 gene and are able to bind and activate GRR54 receptor. The role of KiSS-1/GPR54 ligand-receptor system working generally in the hypothalamus, was described in many species of both sexes including humans.