Follicular dendritic cells development and function

Follicular dendritic cells (follicular dendritic cells, FDC) are distinct antigen-presenting cells, and are different from the dendritic cells of myeloid origin, function and the presence of different surface markers. FDC occur within the zone B cell follicles of secondary lymphoid organs and play a very important role in the development of germinal centers have the ability to capture antigen-antibody complexes, which for a long time (months or even years) may remain on the surface.

Immunological mechanisms in cancer and attempts to use them in immunotherapy

One of the immune surveillance mechanisms to protect the human body against the development of cancer is the presence of monoclonal IgM natural antibodies in the circulation. Routine immunosuppression is a wonderful occasion to carcinogenesis. Such a situation occurs for example after viral infections or is caused by smoking cigarettes. In addition, a growing cancer induces immunological tolerance.

Telomere length and telomerase activity by flow cytometry

Adjust the length of telomeres is crucial in the process of senescencji cell immortalization and tumorigenesis . It occurs mainly due to the activity of telomerase . Telomerase is a DNA polymerase -dependent RNA specific for telomeric sections , which plays a crucial catalytic subunit hTERT (reverse transcriptase ) necessary for enzyme activity. The function of telomere - telomerase has been demonstrated in most tumor cells , stem cells and lymphocytes during differentiation and activation.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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