Disorders of eNOS expression and activity are combined with disease entities such as atherosclerosis , coronary heart disease , hypercholesterolemia and hypertension . The first time was identified eNOS in endothelial cells of veins and arteries ; More detailed studies have shown the presence of this enzyme in myocytes , platelets, and neurons Leydig and Sertoli cells . Endothelial nitric oxide synthase accumulates inwaginacji at specific sites of the cell membrane .

Endothelial nitric oxide synthase ( eNOS ) is one of three enzymes capable of producing nitric oxide ( NO) . This molecule fully key functions in the cardiovascular system . ENOS gene consists of 26 exons and the fragment of chromosome 7 is about the size of 22 kb. Gene promoter does not contain a basic sequence recognized by a complex of RNA polymerase II preinicjacyjny , tzw.TATA box .