Blood platelets, enucleate cells derived from megakaryocytes, play an essential role in haemo- stasis and thrombosis. They may be involved probably in platelet activation and programmed death. The experimental evidences discussed in this review indicate that during aging and activation platelets express apoptotic markers similar to those found in nucleated cells.

The role of reactive oxygen species in platelets

Reactive oxygen species ( ROS) , which include superoxide anion ( O2. ) , hydroxyl radical (OH) , hydrogen peroxide (H2O2) , singlet oxygen ( 1O2 ) and nitric oxide (NO) are highly reactive particles. Can react with lipids, proteins or DNA , causing irreversible changes in the structure of these compounds. Platelets , like other cells , can generate ROS , which are drawn into the mechanisms of activation of these cells . There are several ways to manufacture platelet RFT .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

PBK Postępby biologi komórki