The discovery of endothelial progenitor cells (EPCs) and demonstration of their participation in postnatal new blood vessel formation accelerated their application for therapeutic angiogenesis in cardiovascular diseases and vascularity-dependent disorders treatment. First experiments done on EPCs suggested that usage of these cells in clinic may improve the quality of life of the patients not curable with standard revascularizing surgery. However, the clinical trials of cell therapy with EPCs were not as fruitful as expected.