FIND ARTICLE

Volume: 
Supplement: 
23
Date of issue: 

Diseases of the cardiovascular system have a wide range of social , are the first cause of mortality among all groups. However, treatment with the attack , despite significant progress in this area is far unsatisfactory. In the absence of a sufficiently intensive mechanism for auto - regeneration of myocardial infarction treatment , notably distant in time is basically only symptomatic and do not prevent the adverse remodeling of the body leading to heart failure or even death. The application of tissue engineering has become one of the few methods for the regeneration of irreversibly damaged myocardium after myocardial region . In extensive preclinical studies in mice , rats, rabbits , sheep clearly demonstrated a positive effect on the improvement of stem cells in myocardial contractility and its basic hemodynamic parameters derived from muscle tissue reservoir or from bone marrow. It is emphasized , however, incomplete compatibility between endogenous cardiomyocytes of the recipient and donor cells ectopically transferred . Often, implanted into the heart cells are derived from the same individual , but their electrophysiological stimulus conduction and expression of certain genes are below expectations. Despite this benefices (improved cardiac contractility and ejection fraction ) is evident and statistically significant. In the first phase of clinical studies (including in the present study ) using myoblasts demonstrating the safety of administration of muscle precursor cells on the occasion of cardiac bypass surgery and grafting with transdermal administration , as well as an improvement was observed in patients ejection fraction , after 3-4 months after surgery. Not noticed any significant side effects of administration of autologous myoblasts , which is a factor in encouraging the introduction of phase II studies .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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