FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

The work concerns an important biological process , which is autophagy - phylogenetically old and conservative mechanism , whose role combines , among others, elimination of damaged and (or ) of the cell used in order to prevent the complete degradation . The process of autophagy , being one of the four basic mechanisms of cell death , requires the action of a number of genes and factors supporting . Within autophagy is distinguished by macroautophagy , mikroautofagię , specific autophagy and autophagy -dependent chaperones . Macroautophagy is the removal of the cell fragments or organelles by forming autofagosomu ; mikroautofagia a process for the elimination of smaller elements inwaginację cells by lysosomal membrane ; Specific autophagy takes place only within peroxisomes , and autophagy dependent chaperones occurs only in the presence of heat shock proteins ( hsp ) . Autophagy phenomenon plays an important role in the mechanisms of innate and acquired immunity . Participation in this process were recorded for bacterial infections , and viral infections , and in the process of those involved , inter alia, TLR receptors . Furthermore, the process of autophagy plays an important role both in physiological conditions have been demonstrated its role in stress and the perinatal period and in many pathological conditions such as cancer , liver disease , muscular, nervous , and Crohn's disease .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

PBK Postępby biologi komórki