FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

The mechanism that plays an essential role in immunosuppression and regulation is the presence of naturally arising CD4+CD25+ T lymphocytes (Treg). Quantitative or qualitative dysfunc- tions in these cells may lead to autoimmune diseases. The Foxp3, a forkhead/winged helix (FKH) trans- cription factor, is the key regulatory gene for the development and function of regulatory T lymphocytes. The Foxp3 expression is limited to CD4+CD25+ T cells at both mRNA and protein levels. The Foxp3 interacts with nuclear factor of activated T cells (NFAT) and repress cytokine gene expression. Iduction of the Foxp3 expression in human CD4+CD25- T cells can convert these cells to a regulatory T cell phenotype. This finding may provide new insight into the biology of regulatory T cells and could become a useful therapeutic tool in the treatment of autoimmunity.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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