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CD39 ( NTPDaza 1 ) ? ektoenzym , present in the endothelium and blood cells , plays an important role in the regulation of coagulation , inflammation , and angiogenesis. As a result of the hydrolysis occurs CD39 extracellular ATP and ADP , and consequently to modulate the function of the P2 purinergic receptors . Tri- and diphosphate nucleoside cells induce phenomena as diverse as proliferation, differentiation , chemotaxis or release of cytokines . Inhibition of CD39 , which is a consequence of the activation of endothelial cells and which is accompanied by hypoxia and reperfusion process , leads to the activation and aggregation of platelets . The role of CD39 in angiogenesis indicates severe impairment of the formation of new blood vessels in vivo and in vitro in mice CD39 - / - . The paper presents the current state of knowledge of post-translational modifications of the molecule , CD39 gene groups and potential therapeutic use of CD39 .
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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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