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The ability to obtain mass rearing of small stretches of human tissues and modify their behavior in vitro has led to increased interest in practical application of these achievements in biology and medicine. Conventional treatment of skin defects are not always effective , and there is a need to construct skin substitutes . These may replace the epidermis , but also have been developed full thickness skin equivalents . However, they have next to numerous advantages and disadvantages that lead researchers to seek new solutions . Our experience in this area relate to the use of in vitro cultured autologous epidermal cells in the treatment of trophic leg ulcers . Besides clinical applications is also reconstructed skin use in basic research, among other things, to the analysis of the toxicity of various substances and invasiveness of tumors. Produced in vitro skin substitutes have proved closing means to non-healing wounds , but the bulk of their use is limited because of high production costs.
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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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