FIND ARTICLE

Volume: 
Issue: 
1
Date of issue: 

Phospholipase A2 ( EC 3.1.1.4 , PLA2 ) belongs to a family of enzymes that catalyze the hydrolysis of an ester linkage in the sn-2 position of glycerophospholipids free fatty acids ( TC) , including arachidonic acid (AA ) and lysophospholipids . These compounds may act as secondary messengers in the central nervous system ( CNS). Under physiological conditions, cPLA2 is responsible for the level of KT in cell membranes , stability and fluidity of the membranes and transport processes . CPLA2 activation is caused by an increase in intracellular calcium ion concentration , and phosphorylation of the enzyme protein kinase C ( PKC ) , MAP kinase ( mitogen - acitvated protein kinase) , protein kinase -dependent cGMP ( PKG ) and possibly other kinases . KA excessively released can further be metabolized to bioactive eicosanoids , accompanied by the formation of free radicals , especially O2 - , resulting in neuronal degeneration . In Parkinson's disease (PD ) and other neurodegenerative diseases has been observed activation of phospholipase A2 ( PLA2 ), an increase of AA , the induction of COX -2 (cyclooxygenase 2 ) and an increase in prostaglandin synthesis . The above- mentioned changes cause neurotoxic effects in the brain , and suggest their role in the pathogenesis of Parkinson's disease .

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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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