FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

Current ideas concerning various aspects of the biology of dendritic cells (DC) were presented, including subdivision on two subsets and follow-ups of their activation. The issue of DC cross-presenta- tion (cross-priming) was discussed in detail as an important facet of their immunobiological function. The relevant role of DC in immunoregulation was underlined, particularly the action of immunosuppressive cytokines such as IL-10 and TGF-β and the enzyme indoleamine 2,3-dioxygenase (IDO). Attention was paid to the significance of DC in the induction of immunological tolerance. Evidence was presented for the existence of NK cells with functional and phenotypic features of dendritic cells and at the same time showing cytotoxic properties. In the next section examples of participation of DC in various human diseases were provided including infectious diseases, autoimmunity and immunodeficiencies. Attention was paid to a separate population of follicular dendritic cells, residing in lymphatic nodules of lymph nodes and their role in multiplication of infectious agents active in transmissible spongiform encephalopa- thies. In the final section new perspectives of vaccine production were indicated based on the application of DC linked to biopolymers such as liposomes, nanoparticles and others.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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