Date of issue: 
The development of male reproductive system induced and controlled by hormones produced in the testis differentiation . Androgen insensitivity caused by a mutation of the AR receptor , or the lack of activity of 5a - reductase which convert T to DHT , are the cause of developmental abnormalities and often the cause of male infertility . Similar effects causes no effects of estrogen , resulting from mutations in the cytochrome P450 aromatase gene and a team of resistance to these hormones , caused by mutation of estrogen receptors . As shown by many experimental studies , estrogen acting on fetuses or newborns male animals , may be the cause of developmental abnormalities resulting from an imbalance in the amounts of androgens into estrogens. A significant number of reports documenting the sexual dysfunction of men, an increasing number of cases of the malformation and the fact that in the last 50 years, the number of sperm in the ejaculate of men decreased by at least half , confirms the hypothesis that the environmental hormones may affect the development of male reproductive system and its function , revealing sometimes only after puberty .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email:

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