FIND ARTICLE

Volume: 
Issue: 
4
Date of issue: 

The interest in the influence of drugs on the immune system , with special attention to opiates , according to the Increment is currently the number of addicts and patients stosujšcych morphine to relieve pain . Morphine acts differently on the immune system , hamujšc or nasilajšc response efficiency . Opiates Mogs affect the immune system indirectly bšdź Hanging with classical opioid receptors in the central nervous system , causing increased secretion of catecholamines and glucocorticoids , bšdź Mogs hanging directly with a specific opioid receptor - m3 located on leukocytes . Studies in rodents morphine addicts have shown that the inhibition of the cytotoxic activity of NK cells pośredniczš opioid receptors located in the brain. Studies in vitro environment subject mainly phagocytes potwierdzajš while the theory of a direct action of opiates. It was found that the incubation of leukocytes with morphine inhibits their migration activity by heterologous desensitization of the chemokine receptors . Morphine also reduces the activity of phagocytes żernš , but stimulates the respiratory burst in them . Morphine affects the inflammatory reaction . Given a stimulant together with the peritoneal cavity and reduces the level of leukocyte chemotactic factors in mice and fish, but not in amphibians and birds.
It has been shown that morphine also impairs lymphocyte response by inhibiting their proliferative activity and the production of antibodies .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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