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The expansion of the cumulus granulosa cells ( cumulus oophorus ) occurs in mature ovarian follicles in response to the preovulatory increase of concentration of luteinizing hormone (LH ) in the blood . As a result of intensive extracellular matrix synthesis follicular cumulus oophorus cells move apart , the whole structure multiplies the initial volume , and finally torn off along with the oocyte from the follicle wall granulosa . Since the corona radiata cells have virtually no LH receptors , the drive signal to it tries to expand them through other molecules . These molecules proved to be especially prostaglandin E2 and epidermal growth factors ( EGF) secreted by granulosa cells in the follicle wall , and peptides derived from an oocyte of the superfamily of transforming growth factor b ( TGF- b). Intercellular substance fully distributed corona radiata is composed mainly of hyaluronic acid chains , which bind to other matrix components . These components are secreted by granulosa cells ( wersikan , TSG- 6 , pentraxin 3 ) or derived from blood plasma ( heavy chains inter -alpha- trypsin inhibitor ) . The creation of mice lacking functional genes responsible for the expansion of somatic cells of cumulus oophorus studies show that this process is necessary for the proper conduct of ovulation. The combined abundant , glycoprotein substance follicle cells is accompanied by oocytowi while walking into the fallopian tube by interacting with the epithelium lining the go . They also facilitate fertilization by sperm binding , directing them towards the oocyte , and favoring capacitation and acrosome reaction.

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The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

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