FIND ARTICLE

Volume: 
Issue: 
4
Date of issue: 

Focal Adhesion Kinase - FAK ( focal adhesion kinase) belongs to the group of non-receptor protein tyrosine kinases . It occurs in the cytoplasm of most cells , including osteoblasts. At the time of its activation , the interaction of integrin associated protein extracellular matrix call is incorporated into platelet adhesion . FAK kinase in the presence of these structures is closely related to a function that plays in cellular processes such as adhesion, migration, proliferation . FAK -deficient cells show a much slower growth and reduced mobility. Kinase activates a variety of signal transduction pathways in the cell, leading inter alia to cell differentiation . By controlling the activity of kinases belonging to the group of MAPK ( mitogen -activated protein kinase ) , influences the maturation and differentiation of cells into the osteoblasts in vitro. Indirectly stimulates the activation of genes characteristic of the osteoblast phenotype valid : Runx2 and Osterix . None of the gene encoding a protein prevents the cell differentiation towards osteoblastycznym . In this paper seeks to demonstrate the role the kinase FAK in cell biology , with particular emphasis on osteoblasts.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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