FIND ARTICLE

Volume: 
Issue: 
2
Date of issue: 

Over the last decade was observed significant development of gene therapy strategies in the hematopoietic system from attempts to correct the mutated gene in monogenic diseases to research on the use of gene transfer in the transplant , the treatment of cancer and AIDS. Intensive research therapy based on genetically modified stem cells - the results obtained in animal models to date are encouraging. The use of gene therapy requires improvements in gene transfer methods and to ensure their safety. All gene therapy vectors , both viral and biochemical, are characterized by certain limitations and risks. Improving biochemical and viral vectors subject to the same rules , resulting from the need to overcome the barriers transgene cell membrane , escape from the endosome into the cytoplasm , and finally penetrate into the nucleus and to obtain controlled expression at therapeutic levels . Despite significant methodological progress , ensuring safety of gene therapy is still a challenge and requires further intensive research.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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