FIND ARTICLE

Volume: 
Issue: 
2
Date of issue: 

The importance of the effect of infection with human papilloma virus (HPV) , and the processes of carcinogenesis, apoptosis has been the subject of many studies , but is still little understood. The study aims to present the current knowledge of the impact of HPV infection on selected aspects of the processes of life and death of cells. Apoptosis is a complex process which leads to cell death , wherein the protein plays an important role of BCL - 2 family , as well as the cell cycle regulatory proteins include P53 and pRB . The importance of HPV infection is associated mainly with promoting survival processes include the inactivation of p53 , pRB , p107 , the interaction of viral oncoproteins cyclin cell cycle , degradation of pro-apoptotic proteins (BAX , BAK ), which leads to overexpression of anti-apoptotic proteins , including BCL -2 protein . Based on the literature describes the interaction of viral oncoproteins in a number of cell cycle regulatory proteins , proliferation and apoptosis (p53 , BCL - 2 , BAX , BAK and pRB ) . Particular attention was paid to the role in the inhibition of apoptosis play a viral gene products E6 and E7 . Number of human papillomavirus infection appears to have a significant role in the apoptosis cascade disorders , which can lead to uncontrolled cell proliferation and the development of neoplastic lesions .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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