The most important function of blood platelets is involved in primary hemostasis comprising forming the stud part in the hemostatic and secondary hemostasis , or clotting factor activation and production of thrombin. Platelets are also involved in many physiological and pathological processes , including in wound healing , defense against bacterial infections , metastasis of tumor cells and the formation and development of inflammation and atherosclerosis . Resting platelets do not adhere to unstimulated endothelial cells and do not react with the wall of the blood vessel. Stimulated endothelial cells in inflammatory and atherosclerotic acquire the properties that make them adhere to the plate . The platelet adhesion to endothelial receptors involving many platelets and endothelial cells , multiple cytokines released from platelets , endothelial and leukocyte adhesion proteins and numerous podśródbłonka released from or present in the blood and can attach to the surface of platelets. Platelet adhesion to endothelial cells induces activation of the platelets. Active platelets release their grain to the external environment more substances which alter both the endothelium and platelets . The released substances heighten the activation of cells and alter their adhesion , aggregation , migration , proliferative , chemotactic and proteolytic properties and contribute to accelerating the creation and development of inflammation. Platelets also become activated in inflammatory conditions independently of adhesion to the endothelium , which increases their adhesion to the endothelium . Active tiles interact with other blood cells and attract them to the inflammatory foci in the affected vessel endothelium , exacerbating inflammatory processes . In addition , the active plate , endothelial cells, and leukocytes release microbubbles that are highly procoagulant and pro-inflammatory. Part one shows the receptors responsible for the activation of platelets and endothelial cells in inflammation and participate in interactions between platelets and endothelium , leukocytes and smooth muscle cells . It also describes the role of adhesion molecules and cell-derived microbubbles in blood formation and propagation of inflammation.