FIND ARTICLE

Volume: 
Issue: 
1
Date of issue: 

The NF-kB-dependent signaling pathways are essential components of cellular response to stress. Mammalian family of NF-kB consists of five NF-kB/Rel proteins, which are subunits of the NF-kB transcription factor, and four IkB proteins, which are their specific inhibitors. Activation of NF-kB requires degradation of IkB, which allows nuclear translocation of NF-kB and its binding to cisacting DNA regulatory elements. NF-kB transcription factors regulate expression of numerous genes, which are involved in cell proliferation, apoptosis, immune response and inflammatory response. The NF-kB-dependent signaling pathways interfere with two other stress-related pathways regulated by p53 and HSF1 transcription factors. All three pathways are essential for both pathogenesis of serious human diseases, including cancer, and for response to therapeutic treatment.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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