FIND ARTICLE

Volume: 
Issue: 
3
Date of issue: 

Receptor CD163 of monocytes / macrophages bound hemoglobin and its complexes with haptoglobin ( Hp - Hb ) , the receptor activates a receptor group " scavenger " for hemoglobin ( HbSR ) . Through the uptake and internalization of hemoglobin iron removal occurs as a factor inducing free radical reactions and as a factor increasing the growth and pathogenicity of bacteria. SCD163/HbSR soluble receptor is cleaved from the surface of monocytes by molecular patterns associated with pathogens at the same time , which is likely to hemolysis and the formation of Hb - Hp complexes . The consequences of infection include additional features , especially anti-inflammatory, for CD163/HbSR , beyond binding and internalization of Hb - Hp complexes . The initial innate immune response to infection affects the synthesis of pro-inflammatory cytokines to recruit leukocytes to areas of new tissue and inflammation and inflammatory mediators , additional production , which help to reduce local tissue damage . Inflammatory mediators such as glucocorticoids and interlukina - 10 significantly increase the expression of cell surface CD163/HbSR , while the pro-inflammatory cytokines tumor necrosis factor TNF -a and interferon - gprzeciwnie suppress its expression . Increased surface expression of the receptor can additionally reduce CD163/HbSR part Hb internalized in the cellular pool of iron , thereby limiting the increase in the intracellular pathogens dependent on that component.

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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