FIND ARTICLE

Volume: 
Issue: 
1
Date of issue: 

The tolerance of the organism to potent drugs and methods of treatment ( and such methods are , without exception, the control of hematological malignancies ) depends both on the age and the presence of accompanying diseases . In turn, the occurrence of these disorders increases with age , so these are statistical parameters (although not individually ) correlated. The second issue that must be taken into account here is the possible discrepancy chronological age and biological age in individual patients . Finally, this tolerance is also dependent on the specific type of cancer in an individual chorego.W present depending on the type of the treatment there are various reasons for increasing with age toxicity . With respect to chemotherapy is a general increasing susceptibility to damage internal organs combined with reduced regenerative capacity . With respect to allogeneic bone marrow transplantation is a greater tendency to develop severe graft versus host disease associated with atrophy of the thymus function and, finally, with respect to monoclonal antibodies , and other immunosuppressive drugs is strongly lower the ability of the immune system resulting in the renewal of long-term immunosuppression . However, apart from patients who underwent a number of courses of chemotherapy is not observed hematologic worse health in the elderly. A total effect is that not apply intensive chemotherapy in people older than 70 ± 5 years , transplantation of autologous bone in people older than 65 ± 5 years in myeloma and 60 ± 5 years in acute leukemias . From allogeneic bone marrow transplantation is limited by donor age, family 55 ± 5 years , and allogeneic transplantation from unrelated donor age 45 ± 5 years .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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