FIND ARTICLE

Volume: 
Issue: 
1
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The cause of proteinuria in idiopathic nephrotic syndromes in children is increased permeability of the glomerular filtration barrier following the action of immune and non-immune . Podocytes , thanks to specific proteins of the cytoskeleton ( cytokeratin , vimentin , actin ) and particles stabilizing their intracellular organization (complex podokaliksyna - ezryna - On exchanger regulatory factor -H - actin , synaptopodin ) and proteins films fissured ( podocyn , nephrin ) are responsible for the proper filtration process in the glomerulus . Elements of the filter membrane may be damaged in inflammatory processes . Particular importance is given to inflammatory cytokines (including endothelial growth factor , VEGF ) and lectins (e.g. galectin -1). Furthermore , morphologically immature glomeruli may be characterized by impaired filtration , which may in turn cause proteinuria refractory to treatment in children. The paper presents current views on the importance of wymienionychbiałek in the pathogenesis , course and prognosis teams nephrotic children .

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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