Dendritic cells (DC ) are the most important antigen-presenting cells (APCs ) to T lymphocytes ripeness DC cells is crucial for the type of T cell response Immature DC induces cell tolerance state , while the mature cell DC - a full immune response. This is very important in transplantation , and in particular of graft rejection reactions after organ transplantation . DC donor cell presents the antigen in a direct way , whereas DC recipient cell in an indirect way . DC cells are immature or tolerogenic properties may prolong allograft survival . Such an influence on the function of DC , so that they are insensitive to signals or in vivo maturation of DC activation characterized by permanent tolerogenic properties may improve the tolerance of the graft. For this purpose, the cultures were carried out under specific conditions , pharmacological and genetic engineering.