FIND ARTICLE

Volume: 
Supplement: 
18
Date of issue: 

The role of receptor A g -aminobutyric acid ( GABA ) in the neural control of the release gonadotropin-releasing hormone (GnRH ) from the hypothalamus in sheep anestralnych determined from the extracellular concentration of GnRH , b- endorphin , noradrenaline , dopamine and its metabolites DOPAC and MHPG during perfusion and bicuculliny muscimolu ( agonists and antagonists of the GABAA receptors ) in the kernel funnel ? median eminence (NI / ME ) and the preoptic area ( MPOA ) . Stimulation of GABAA receptors in the NI / ME decreased the concentration of GnRH , b- endorphin and dopamine and MHPG and DOPAC , but had no effect on plasma norepinephrine. Blocking GABAA receptors in the hypothalamus this structure does not cause significant changes in the concentration of GnRH , norepinephrine and MHPG , and lowered plasma b- endorphin , dopamine and DOPAC . The MPOA perfusion muscimolu increased the concentration of noradrenaline and MHPG , and decreased levels of dopamine and DOPAC . No significant changes in the levels of GnRH and beta- endorphin , and observed a significant reduction in the release of gonadotropins (LH) . Perfusion bicuculliny had no significant effect on the level of these compounds. The results suggest that GABA may inhibit the secretion of GnRH by GABAA receptors in the MPOA and NI / ME both directly by neural receptors at the ends or on perikarionach GnRH or indirectly through these receptors on neurons or catecholaminergic opioidergicznych these structures in the hypothalamus .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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