FIND ARTICLE

Volume: 
Supplement: 
18
Date of issue: 

Mammary gland during its development goes through several stages , which are regulated by hormones , the interaction with epithelial cells and the tissue factors from the extracellular matrix ( extracellular matrix) . Molecular mechanisms of most of these processes are little explored. One group of genes for the epithelium - mesenchyme interaction in embryonic Hox genes belonging to the family Muscle -Segment Homeobox ( Msx ) . Expression of Msx interaction occurs in the epithelium - mesenchyme and is essential for the development of the limbs, the teeth and bearings . Msx transcription factors regulate the expression of genes directly ? by binding to specific DNA sequences in the promoter and / or the respective genes enhancerach or indirectly ? by forming complexes with other transcription factors to increase or decrease the affinity of MSX2 to a specific DNA sequence . In the mammary gland to express all the genes , the products of which form a complex with MSX2 transcription and its expression level is closely correlated with the growth and branching of the milk ducts . This allows you to hypothesize that Msx transcription factors are involved in signal transduction of estrogen and progesterone to genes regulating cell division bubbles in milk germs and branching of the mammary ducts .

Author of the article: 

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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