FIND ARTICLE

Volume: 
Issue: 
2
Date of issue: 

MAP kinases , which include three families : the ERK , JNK and p38 , are intracellular signaling pathways by which signals can be received from the biological response of the receptor and a cell, and their activity determines the proper functioning of the immune system. MAP kinases are involved in the activation of the innate defense mechanisms involved in the cytokine production under the influence of signals from TLR receptors , and effector pathways are at the same time , which enable the cell response to cytokines. Among the mechanisms of specific immunity MAP kinases are essential for the differentiation of T and B cells via activation pathways dependent on ITAM domains. Furthermore, their participation in the process of apoptosis and cytotoxicity assisted by T-lymphocytes and allows the removal of damaged cells , infected or transformed. Because of the involvement of MAP kinases in the immune response and their inhibitors are promising therapeutic tool.

The Editorial Board
Andrzej Łukaszyk - przewodniczący, Zofia Bielańska-Osuchowska, Szczepan Biliński, Mieczysław Chorąży, Aleksander Koj, Włodzimierz Korochoda, Leszek Kuźnicki, Aleksandra Stojałowska, Lech Wojtczak

Editorial address:
Katedra i Zakład Histologii i Embriologii Uniwersytetu Medycznego w Poznaniu, ul. Święcickiego 6, 60-781 Poznań, tel. +48 61 8546453, fax. +48 61 8546440, email: mnowicki@ump.edu.pl

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